国家卫健委功能性脑疾病诊治重点实验室

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研究方向(含承担课题) 著作论文

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研究方向(含承担课题)

利用计算生物学和生物信息学的手段发现和解析抑郁症的发生发展过程中基因组、转录组、蛋白组和代谢组等多维度分子变化规律，帮助抑郁症致病机制的深入理解和新的诊断方法的开发。

著作论文

1. Siwen Gui#; Yiyun Liu; Juncai Pu; Xuemian Song; Xiaopeng Chen; Weiyi Chen; Xiaogang Zhong;Haiyang Wang; Lanxiang Liu; Peng Xie ; Comparative analysis of hippocampal transcriptional features between major depressive disorder patients and animal models, Journal of Affective Disorders, 2021, Oct 1(293): 19-28.

2. Juncai Pu; Yiyun Liu; Siwen Gui#; Lu Tian; Yue Yu; Xuemian Song; Xiaogang Zhong; Xiaopeng; Chen; Weiyi Chen; Peng Zheng; Hanping Zhang; Xue Gong; Lanxiang Liu; Jing Wu; Haiyang Wang; Peng Xie ; Metabolomic changes in animal models of depression: a systematic analysis, Molecular Psychiatry, 2021, Dec 26(12): 7328-7336.

3. Yiyun Liu; Haiyang Wang; Siwen Gui#; Benhua Zeng; Juncai Pu; Peng Zheng; Li Zeng; Yuanyuan; Luo; You Wu; Chanjuan Zhou; Jinlin Song; Ping Ji; Hong Wei; Peng Xie ; Proteomics analysis of the gut-brain axis in a gut microbiota-dysbiosis model of depression, Translational Psychiatry, 2021, 11(1): 0-568.

4. Xuemian Song; Yiyun Li; Juncai P; Siwen Gui#; Xiaogang Zhong; Xiaopeng Che; Weiyi Che; Xiang Chen; Yue Chen; Haiyang Wang; Ke Chen; Libo Zhao; Peng Xie. Transcriptomics Analysis Reveals Shared Pathways in Peripheral Blood Mononuclear Cells and Brain Tissues of Patients With Schizophrenia. Frontiers in Psychiatry. 2021 Sep 22;12:716722.

5. Siwen Gui#; Yiyun Liu; Xiaogang Zhong; Xinyu Liu; Peng Zheng; Juncai Pu; Jian Zhou;Jianjun Chen; Libo Zhao; Lanxiang Liu; Guowang Xu; Peng Xie ; Plasma disturbance of phospholipid metabolism in major depressive disorder by integration of proteomics and metabolomics, Neuropsychiatric Disease and Treatment, 2018, June 6(14): 1451-1461.