1）研究方向：抑郁症的分子机制研究。

2) 擅长技术：熟练掌握常规分子生物学（WB, PCR，ELISA，IF，RNAscope等），293细胞系和海马原代神经元培养。熟练操作脑片全细胞膜片钳记录和海马场电位记录和抑郁模型建模/转基因小鼠抑郁模型及抑郁焦虑相关行为学评估。大/小鼠脑立体定位注射和埋管手术。人脑脑片多通道膜片钳记录和扫描电镜等技术。

1. Ke Cheng^#, et al, Hua-tai Xu, Peng Xie. The deficit of hippocampal carbonic anhydrase 1 causes depression-like behaviors. Acta Neuropathologica Communications 2023 Apr 3;11(1):59. (IF:7.5)

2. Wang Y, Chen X, Chen Z, Yu H, Tian Y, He Y, Cheng K, Xie P. Disturbances of phosphatidylcholines metabolism in major depressive disorder CNS Spectr. 2023 Jan 17:1-9.

3. Cheng, K^#., Li, J., Yang, D., Yang, Y., Rao, C., Zhang, S., Wang, W., Guo, H., Fang, L., Zhu, D., et al. (2016). 2D-gel based proteomics unravels neurogenesis and energetic metabolism dysfunction of the olfactory bulb in CUMS rat model. Behavioural brain research 313, 302-309.

4. Mengge Bai , et., al, Ke Cheng*, Peng Xie. (2022) Pigment epithelium-derived factor may induce antidepressant phenotypes in mice by the prefrontal cortex. Neuroscience Letter. DOI: 10.1016/j.neulet.2021.136423

5. Jie Liu, et., al, Ke Cheng*, Peng Xie.(2020) Changed PGA and POSTN levels in choroid plexus are associated with depressive-like behaviors in mice. Biochemical and Biophysical Research Communications. DOI: 10.1016/j.bbrc.2020.01.076.

6. Yan Li, et., al, Ke Cheng*, Peng Xie. (2022), The Neurotransmitter and Related Metabolite of GABAergic, Serotonergic and Catecholaminergic Pathway Changed in the Nucleus Accumbens of CUMS Rats. Frontiers in Behavioral Neuroscience.

7.Chenmeng Li,  Ke Cheng., Activation of ERK/CREB/BDNF pathway involved in abnormal behavior of neonatally Borna virus-infected rats. Neuropsychiatr Dis Treat. 2018 Nov 15;14:3121-3132. doi: 10.2147/NDT.S176399. eCollection 2018.

8. Yong He, et., al, Ke Cheng*, Peng Xie.(2019) The 25(OH)D/VDR signaling may play a role in major depression. Biochemical and Biophysical Research Communications. DOI: 10.1016/j.bbrc.2019.12.071.

9. Yue Wang, et., al, Ke Cheng*, Peng Xie. (2021) Ferritin disorder in plasma and hippocampus associated with major depressive disorder. Biochemical and Biophysical Research Communications. DOI:10.1016/j.bbrc.2021.03.059

10. Yong He, et al, Ke Cheng*, Peng Xie*. (2020) Major depression accompanied with inflammation and multiple cytokines alterations: Evidences from clinical patients to macaca fascicularis and LPS-induced depressive mice model. Journal of Affective Disorders.doi.org/10.1016/j.jad.2020.03.131.