研究方向(含承担课题)

主要从事神经系统感染与免疫相关周围神经疾病研究。现围绕乙型脑炎病毒感染诱导宿主周围神经损伤，通过UPLC-HILIC-FLD、CUT&Tag、冷冻电镜等开展靶抗原模拟物机制、Fc聚糖修饰及其与效应细胞互作的分子调控和免疫复合物及其与FcγRs的结构生物学研究。

以第一作者（含共同）在The New England Journal of Medicine, Emerging Microbes & Infection等期刊发表学术论文8篇，单篇最高影响因子91.245。中国学者2020年国际四大顶级医学期刊论文学术影响力科学计分1268.16分。先后参与申报并完成国家自然科学基金面上项目和省级重点（重大）专项各2项。作为副主编撰写《流行性乙型脑炎基础与临床》专著1部。获省级自然科学优秀学术论文一等奖1项（排名第1），省级科技进步二等奖1项（排名第3），参与申报国家发明专利4项。

著作论文

1. Guowei Wang*, Haining Li, Xiaojun Yang, Tao Guo, Libin Wang, Zhijun Zhao, Haifeng Sun, Xiaolin Hou, Xiangchun Ding, Chunyang Dou, Qiaoli Ma, Xiao Yang, Yanbo Wang, Zhao Wang, Luxuan Wang, Jixiang Liu, Zhenhai Wang, Huanyu Wang, Peng Xie. Guillain-Barré Syndrome Associated with JEV Infection. N Engl J Med. 2020 Sep 17;383(12):1188-1190. (IF: 91.245)

2. Guowei Wang*, Lianmei Zhong*, Manxia Wang*, Juan Zhou*, Shuting Liu, Wang Miao, Leilei Li, Yonghong Liu, Shougang Guo, Haining Li, Xiaoming Wang, Liuqing Xie, Min Xie, Shihong Fu, Tingting Xuan, Fan Li, Tingting Yang, Lufei Shao, Mingfang Shi, Xiaocong Li, Xiaoling Li, Li Gao, Shaopeng Zhai, Jia Ding, Tianhong Wang, Dayong Liu, Guosheng Ma, Jiang Wu, Dongjun Wan, Junlin Guo, Xinbo Zhang, Jinxia Wu, Yinxu Wang, Ansong Jin, Lei Ma, Huan Yang, Xuexian He, Xiaona Ma, Huijuan Liu, Boya Ma, Ningai Yang, Xiaolin Hou, Ting Xu, Cheng-Feng Qin, Huanyu Wang, Peng Xie, Zhenhai Wang. Peripheral nerve injury associated with JEV infection in high endemic regions, 2016-2020: a multicenter retrospective study in China. Emerg Microbes Infect. 2024 Dec;13(1):2337677. (IF: 13.2)

3. Fan Li*, Yun Feng*, Guowei Wang*, Weijia Zhang, Shihong Fu, Zuosu Wang, Qikai Yin, Kai Nie, Juying Yan, Xuan Deng, Ying He, Liang Liang, Songtao Xu, Zhenhai Wang, Guodong Liang, Huanyu Wang. Tracing the spatiotemporal phylodynamics of Japanese encephalitis virus genotype I throughout Asia and the western Pacific. PLoS Negl Trop Dis. 2023 Apr 13;17(4):e0011192. (IF: 4.8)

4. Xiaoli Wang*, Guowei Wang*, Huan Yang, Shihong Fu, Ying He, Fan Li, Huanyu Wang, Zhenhai Wang. A mouse model of peripheral nerve injury induced by Japanese encephalitis virus. PLoS Negl Trop Dis. 2022 Nov 28;16(11):e0010961. (IF: 4.4)

5. Zhao Wang*, Guowei Wang*, Yanbai Wang, Qiang Liu, Haining Li, Peng Xie, Zhenhai Wang. Omp31 of Brucella Inhibits NF-κB p65 Signaling Pathway by Inducing Autophagy in BV-2 Microglia. Neurochem Res. 2021 Dec;46(12):3264-3272. (IF: 4.0)

6. Luxuan Wang*, Guowei Wang*, Yangyang Duan, Feng Wang, Shaoqing Lin, Fengting Zhang, Hui Li, Andy Li, Haining Li. A Comparative Study of the Diagnostic Potential of Plasma and Erythrocytic α-Synuclein in Parkinson's Disease. Neurodegener Dis. 2019;19(5-6):204-210. (IF: 2.4)

7. Huan Yang, Xiaoli Wang, Zhao Wang, Guowei Wang, Shihong Fu, Fan Li, Liping Yang, Yanping Yuan, Kaichun Shen, Huanyu Wang, Zhenhai Wang. Peripheral Nerve Injury Induced by Japanese Encephalitis Virus in C57BL/6 Mouse. J Virol. 2023 May 31;97(5):e0165822. (IF: 6.5)