国家卫健委功能性脑疾病诊治重点实验室

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研究方向(含承担课题) 著作论文

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研究方向(含承担课题)

致力于抑郁症及自杀的发病机制和相关治疗策略研究。通过靶向代谢组学分析等方法，筛选内源性小分子代谢物，旨在寻找安全性较高，有助于解决抑郁症临床诊治困境的抗抑郁天然物质。

著作论文

1. Fan L^#, Yang L, Li X, et al. Proteomic and metabolomic characterization of amygdala in chronic social defeat stress rats [J]. Behavioural brain research, 2021, 412: 113407.

2. Teng T, Fan L^#, Yan W, et al. A diathesis-stress rat model induced suicide-implicated endophenotypes and prefrontal cortex abnormalities in the PKA and GABA receptor signaling pathways [J]. Progress in neuro-psychopharmacology & biological psychiatry, 2022, 116: 110538.

3. Wang J, Fan L^#, Teng T, et al. Adolescent male rats show altered gut microbiota composition associated with depressive-like behavior after chronic unpredictable mild stress: Differences from adult rats [J]. Journal of psychiatric research, 2024, 173: 183-9.

4. Tian T, Xu B, Qin Y, Fan L^#,et al. Clostridium butyricum miyairi 588 has preventive effects on chronic social defeat stress-induced depressive-like behaviour and modulates microglial activation in mice [J]. Biochemical and biophysical research communications, 2019, 516(2): 430-6.