国家卫健委功能性脑疾病诊治重点实验室

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研究方向(含承担课题) 著作论文

导航菜单

研究方向(含承担课题)

借助系统行为学，光纤记录，光遗传和化学遗传，离体和在体电生理，分子生化等技术手段研究慢性应激导致抑郁的分子，细胞和神经环路机制。

著作论文

1. Yong He#, Yue Wang#, Heming Yu, Yu Tian, Xiangyu Chen, Chong Chen, Yikun Ren, Zhi Chen, Yi Ren, Xue Gong, Ke Cheng, Xiaolei Liu, Lianmei Zhong*, Yi Guo*,Peng Xie*. Protective effect of Nr4a2 (Nurr1) against LPS-induced depressive-like behaviors via regulating activity of microglia and CamkII neurons in anterior cingulate cortex. Pharmacological research, 2023 Mar 21;191:106717，doi: 10.1016/j.phrs.2023.106717.

2. Yong He, Wei Li, Yue Wang, Yu Tian, Xi Chen, Zhonghao Wu, Tianlan Lan, Yan Li, Mengge Bai, Jie Liu, Ke Chen*, Peng Xie*. Journal of Affective disorders, Volume 271,15 June 2020, Pages 262-271,doi:10.1016/j.jad.2020.03.131.

3. Yong He, Yue Wang, Zhonghao Wu, Tianlan Lan, Yu Tian, Xi Chen, Yan Li, Ruozhi Dang, Mengge Bai, Ke Cheng*, Peng Xie*. Metabolomic abnormalities of purine and lipids implicated olfactory bulb dysfunction of CUMS depressive rats. Metabolic Brain Disease, 2020 Apr; 35(4);649-659;doi:10.1007/s11011-020-00557-8.

4. Yong He#,, Zhonghao Wu#,, Tianlan Lan, Yue Wang, Yu Tian, Xi Chen, Yan Li, Mengge Bai, Jie Liu, Xue Gong, Ke Cheng*, Peng Xie*.The 25(OH)D/VDR signaling may play a role in major depression (Biochemical and Biophysical Research Communication, 2020 Mar 5;523(2):405-410. doi: 10.1016/j.bbrc.2019.12.071.

5. Yong He#, Wei Li#,, Yu Tian#,, Xi Chen#,, Ke Cheng#,, Ke Xu, Chenmeng Li, Haiyang Wang, Chaohua Qu, Chunlian Wang, Pengfei Li, Huanxin Chen*, Peng Xie*. iTRAQ-based proteomics suggests LRP6, NPY and NPY2R perturbation in the hippocampus involved in CSDS may induce resilience and susceptibility. Life Sciences, 2018 Oct 15;211:102-117. doi: 10.1016/j.lfs.2018.09.016.

6. Xi Chena#, Yong He#, Yu Tianb#, Yue Wang# , Zhonghao Wu, Tianlan Lan, Haiyang Wang, Ke Cheng*, Peng Xie*. Different serotypes of AAV vectors and lentivirus meditated tropism in choroid plexus by intracerebroventricular delivery