The 5D respiratory interventional system in the Department of Respiratory and Critical Care Medicine covers four dimensions - trans-airway, trans-pulmonary vasculature, percutaneous transthoracic, and transesophageal approaches - combined with thoracic surgery-assisted respiratory intervention. This comprehensive, three-dimensional, minimally invasive interventional approach for precise diagnosis and treatment of pulmonary diseases was pioneered and successfully established by Professor GUO Shuliang, one of the inaugural National Outstanding Physicians. As a groundbreaking paradigm in the construction of respiratory interventional systems nationwide, the 5D system has significantly enhanced the overall framework and capabilities for respiratory interventions, substantially improving treatment success rates and propelling the discipline into a “fast track” of development. Its pronounced advantages overcome the limitations of traditional respiratory intervention, enabling precise diagnosis and minimally invasive treatment for conditions such as early lung cancer and massive hemoptysis. In addition, its research findings have been published repeatedly in internationally authoritative journals and have received extensive international recognitions, with Italian experts highly praising it as a “highly distinctive and attractive” technology.